abstract：:Paragangliomas (PGLs) are rare vascular, neuroendocrine tumors of paraganglia, which are associated with either sympathetic tissue in adrenal (pheochromocytomas (PCCs)) and extraadrenal (sympathetic paraganglioma (sPGLs)) locations or parasympathetic tissue of the head and neck paragangliomas (HNPGLs). As HNPGLs are u...

journal_title：European journal of endocrinology

authors： Corssmit EP,Romijn JA

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Clinical presentation of pituitary adenomas frequently involves pain, particularly headache, due to structural and functional properties of the tumour. Our aim was to investigate the clinical characteristics of pain in a large cohort of patients with pituitary disease. DESIGN:In a cross-sectional study, we a...

journal_title：European journal of endocrinology

authors： Dimopoulou C,Athanasoulia AP,Hanisch E,Held S,Sprenger T,Toelle TR,Roemmler-Zehrer J,Schopohl J,Stalla GK,Sievers C

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this meta-analysis was to examine the evidence for the effectiveness of aerobic exercise interventions on reducing insulin resistance markers in obese children and/or adolescents. A secondary outcome was change in percentage of body fat. METHODS:A computerized search was made from seven databa...

journal_title：European journal of endocrinology

authors： García-Hermoso A,Saavedra JM,Escalante Y,Sánchez-López M,Martínez-Vizcaíno V

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the influence of age on the association between thyroid function and mortality. DESIGN:The Nijmegen Biomedical Study is a population-based study, comprising 5816 randomly selected adults of all age groups without previously known thyroid disease. METHODS:TSH, free th...

journal_title：European journal of endocrinology

authors： van de Ven AC,Netea-Maier RT,de Vegt F,Ross HA,Sweep FC,Kiemeney LA,Smit JW,Hermus AR,den Heijer M

更新日期：2014-08-01 00:00:00

abstract：:Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence has increased in recent decades. Initial treatment usually consists of total thyroidectomy followed by ablation of thyroid remnants by iodine-131. As thyroid cells are assumed to be the only source of thyroglobulin (Tg) in the hu...

journal_title：European journal of endocrinology

authors： Giovanella L,Clark PM,Chiovato L,Duntas L,Elisei R,Feldt-Rasmussen U,Leenhardt L,Luster M,Schalin-Jäntti C,Schott M,Seregni E,Rimmele H,Smit J,Verburg FA

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Mortality in acromegaly strictly depends on optimal control of GH and IGF1 levels. Modern medical therapy with somatostatin analogs (SSAs) and GH receptor antagonists (GHRAs) is not available in many countries due to funding restrictions. This retrospective, comparative, cohort study investigated the impact ...

journal_title：European journal of endocrinology

authors： Colao A,Vandeva S,Pivonello R,Grasso LF,Nachev E,Auriemma RS,Kalinov K,Zacharieva S

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:HDLs have many diverse functions. The goal of this study was to determine the association of HDL cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) with the development of type 2 diabetes (T2D). In particular, this study determined the association between the ratio of HDL-C to apoA-I (HA) and incident T2D. ...

journal_title：European journal of endocrinology

authors： Hwang YC,Ahn HY,Park SW,Park CY

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality. DESIGN:Cross-sectional study. METHODS:A total of 15 craniopharyngioma patients were individually matched to healthy controls. In this stud...

journal_title：European journal of endocrinology

authors： Pickering L,Jennum P,Gammeltoft S,Poulsgaard L,Feldt-Rasmussen U,Klose M

更新日期：2014-06-01 00:00:00

abstract：:Puberty is the period during which we attain adult secondary sexual characteristics and reproductive capability. Its onset depends upon reactivation of pulsative GNRH, secretion from its relative quiescence during childhood, on the background of intact potential for pituitary-gonadal function. This review is intended:...

journal_title：European journal of endocrinology

authors： Dunkel L,Quinton R

更新日期：2014-06-01 00:00:00

abstract：:Giant prolactinomas are rare tumours, representing only 2-3% of all prolactin (PRL)-secreting tumours and raising special diagnostic and therapeutic challenges. Based on several considerations developed in this review, their definition should be restricted to pituitary adenomas with a diameter of 40  mm or more, signi...

journal_title：European journal of endocrinology

authors： Maiter D,Delgrange E

更新日期：2014-06-01 00:00:00

abstract：:For patients with neuroendocrine tumours (NETs) of the gastrointestinal tract and pancreas (GEP) (GEP-NETs), excellent care should ideally be provided by a multidisciplinary team of skilled health care professionals. In these patients, a combination of nuclear medicine imaging and conventional radiological imaging tec...

journal_title：European journal of endocrinology

authors： de Herder WW

更新日期：2014-04-10 00:00:00

abstract：OBJECTIVE:Serum sclerostin levels have been reported to be inversely associated with serum 25OHD levels, but the effect of vitamin D and calcium supplementation on serum sclerostin levels is unknown. This study was carried out to determine whether vitamin D and calcium supplementation altered serum sclerostin levels in...

journal_title：European journal of endocrinology

authors： Dawson-Hughes B,Harris SS,Ceglia L,Palermo NJ

更新日期：2014-03-13 00:00:00

abstract：INTRODUCTION:Patients with craniopharyngioma (CP) have disturbances of the hypothalamic-pituitary axis and serious comorbidities such as obesity. We hypothesized that the secretion of hormones regulating the nutritional status is altered in adult patients with CP compared with patients with non-functioning pituitary ad...

journal_title：European journal of endocrinology

authors： Roemmler-Zehrer J,Geigenberger V,Störmann S,Losa M,Crippa V,Otto B,Bidlingmaier M,Dimopoulou C,Stalla GK,Schopohl J

更新日期：2014-03-13 00:00:00

abstract：OBJECTIVE:To assess the individuals' thyroid volume changes after the mandatory nationwide iodine fortification (IF) program in two Danish areas with different iodine intake at baseline (Copenhagen, mild iodine deficiency (ID) and Aalborg, moderate ID). DESIGN:A longitudinal population-based study (DanThyr). METHODS:...

journal_title：European journal of endocrinology

authors： Krejbjerg A,Bjergved L,Pedersen IB,Carlé A,Jørgensen T,Perrild H,Ovesen L,Rasmussen LB,Knudsen N,Laurberg P

更新日期：2014-03-08 00:00:00

abstract：OBJECTIVE:To investigate the association between plasma vitamin D (VD) levels and histological liver damage in children with nonalcoholic fatty liver disease (NAFLD). SUBJECTS AND METHODS:In this cross-sectional study, carried out in a tertiary care center for obesity, 73 consecutive overweight and obese children with...

journal_title：European journal of endocrinology

authors： Nobili V,Giorgio V,Liccardo D,Bedogni G,Morino G,Alisi A,Cianfarani S

更新日期：2014-03-08 00:00:00

abstract：OBJECTIVE:Anti-inflammatory glucocorticoid (GC) therapy often induces hyperglycemia due to insulin resistance and islet-cell dysfunction. Incretin-based therapies may preserve glucose tolerance and pancreatic islet-cell function. In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase...

journal_title：European journal of endocrinology

authors： van Genugten RE,van Raalte DH,Muskiet MH,Heymans MW,Pouwels PJ,Ouwens DM,Mari A,Diamant M

更新日期：2014-02-04 00:00:00

abstract：OBJECTIVE:Glucocorticoids stimulate several steps in red blood cell (RBC) development; however, little is known on changes in erythroid parameters in patients with Cushing's disease. The aim of this study was to assess both RBC and white blood cell (WBC) parameters in a large cohort of patients with Cushing's disease a...

journal_title：European journal of endocrinology

authors： Ambrogio AG,De Martin M,Ascoli P,Cavagnini F,Pecori Giraldi F

更新日期：2014-02-04 00:00:00

abstract：OBJECTIVE:To stop smoking is commonly associated with significant weight gain, but the mechanisms for this are poorly understood. We assessed the effects of smoking cessation on body weight, insulin sensitivity, β-cell function, and appetite. SUBJECTS AND METHODS:Twenty-seven long-term smokers (n=27; nine females/18 m...

journal_title：European journal of endocrinology

authors： Stadler M,Tomann L,Storka A,Wolzt M,Peric S,Bieglmayer C,Pacini G,Dickson SL,Brath H,Bech P,Prager R,Korbonits M

更新日期：2014-02-01 00:00:00

abstract：CONTEXT:The TIMES2 (testosterone replacement in hypogonadal men with either metabolic syndrome or type 2 diabetes) study reported beneficial effects of testosterone replacement therapy (TRT) on insulin resistance and other variables in men with diabetes or metabolic syndrome. The androgen receptor CAG repeat polymorphi...

journal_title：European journal of endocrinology

authors： Stanworth RD,Akhtar S,Channer KS,Jones TH

更新日期：2013-12-21 00:00:00

abstract：OBJECTIVE:To characterise distinctive clinical features of giant prolactinomas in women. DESIGN:A multicentre, retrospective case series and literature review. METHODS:We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 μg/l and identified 19 similar case...

journal_title：European journal of endocrinology

authors： Delgrange E,Raverot G,Bex M,Burman P,Decoudier B,Devuyst F,Feldt-Rasmussen U,Andersen M,Maiter D

更新日期：2013-11-22 00:00:00

abstract：BACKGROUND:Glucocorticoids are the mainstay of immunosuppression for active moderate-severe Graves' orbitopathy (GO). AIM:To analyze the response to therapy and the contribution of glucocorticoid receptor (GR) gene polymorphisms to the therapeutic outcome of intravenous glucocorticoids (IVGC) in active moderate-severe...

journal_title：European journal of endocrinology

authors： Vannucchi G,Covelli D,Campi I,Origo D,Currò N,Cirello V,Dazzi D,Beck-Peccoz P,Salvi M

更新日期：2013-11-22 00:00:00

abstract：BACKGROUND:Conventional glucocorticoid (GC) replacement for patients with adrenal insufficiency (AI) is inadequate. Patients with AI continue to have increased mortality and morbidity and compromised quality of life despite treatment and monitoring. OBJECTIVES:i) To review current management of AI and the unmet medica...

journal_title：European journal of endocrinology

authors： Grossman A,Johannsson G,Quinkler M,Zelissen P

更新日期：2013-10-21 00:00:00

abstract：OBJECTIVE:Untreated hypothyroidism is common in iodine-replete areas. Frequent thyroid function testing and use of levothyroxine treatment for subclinical hypothyroidism suggest that the prevalence may have decreased. Therefore, in this study, we examined changes in the prevalence of hypothyroidism in a Norwegian count...

journal_title：European journal of endocrinology

authors： Asvold BO,Vatten LJ,Bjøro T

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To assess whether TCF7L2 single nucleotide polymorphisms rs7903146 C/T and rs11196236 C/T are associated with polycystic ovary syndrome (PCOS) in South Brazilian women. DESIGN:Cross-sectional study. METHODS:Two hundred PCOS patients and 102 non-hirsute, ovulatory controls were genotyped by real-time PCR. Ha...

journal_title：European journal of endocrinology

authors： Ramos RB,Wiltgen D,Spritzer PM

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:Our aim was to analyze a large cohort of childhood onset GH deficiency (CO-GHD) adults from a unique adult center, in order to analyze their clinical management and to study the metabolic and bone status in relation to GHD and to the other pituitary deficits, and to evaluate these parameters during the long-...

journal_title：European journal of endocrinology

authors： Courtillot C,Baudoin R,Du Souich T,Saatdjian L,Tejedor I,Pinto G,Léger J,Polak M,Golmard JL,Touraine P,Transition GHD Group.

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:This study evaluated the short- and long-term cardiovascular- and cancer-related morbidities during cross-sex hormone therapy in a large sample of trans persons. SUBJECTS AND METHODS:A specialist center cross-sectional study compared 214 trans women (male-to-female transsexual persons) and 138 trans men (fem...

journal_title：European journal of endocrinology

authors： Wierckx K,Elaut E,Declercq E,Heylens G,De Cuypere G,Taes Y,Kaufman JM,T'Sjoen G

更新日期：2013-09-13 00:00:00

abstract：OBJECTIVE:To i) compare incretin responses to oral glucose and mixed meal of diabetic patients with the normoglycaemic population and ii) to investigate whether incretin responses are associated with hypertriglyceridaemia and alanine aminotransferase (ALT) as liver fat marker. DESIGN:A population-based study. METHODS...

journal_title：European journal of endocrinology

authors： Alssema M,Rijkelijkhuizen JM,Holst JJ,Teerlink T,Scheffer PG,Eekhoff EM,Gastaldelli A,Mari A,Hart LM,Nijpels G,Dekker JM

更新日期：2013-09-12 00:00:00

abstract：OBJECTIVE:Thyroid dysfunction predicts poorer health outcomes, but the relationship between thyroid hormone levels within the reference range and mortality in older adults remains unclear. In this study, we examined the associations between the concentrations of free thyroxine (FT4) and TSH and all-cause mortality in o...

journal_title：European journal of endocrinology

authors： Yeap BB,Alfonso H,Hankey GJ,Flicker L,Golledge J,Norman PE,Chubb SA

更新日期：2013-09-12 00:00:00

abstract：:Systematic studies of autosomal dominant osteopetrosis (ADO) were followed by the identification of underlying mutations giving unique possibilities to perform translational studies. What was previously designated ADO1 turned out to be a high bone mass phenotype caused by a missense mutation in the first propeller of ...

journal_title：European journal of endocrinology

authors： Bollerslev J,Henriksen K,Nielsen MF,Brixen K,Van Hul W

更新日期：2013-07-13 00:00:00

abstract：OBJECTIVE:For patients who remain hypothyroid despite the administration of what would seem adequate doses of levothyroxine (L-T4), the underlying cause can be difficult to determine. The possibility of a biological cause should first be explored; however, in the majority of cases, poor adherence to medication is likel...

journal_title：European journal of endocrinology

authors： Walker JN,Shillo P,Ibbotson V,Vincent A,Karavitaki N,Weetman AP,Wass JA,Allahabadia A

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Ghrelin stimulates GH secretion and regulates energy and glucose metabolism. The two circulating isoforms, acyl (AG) and des-acyl (DAG) ghrelin, have distinct metabolic effects and are under active investigation for their therapeutic potentials. However, there is only limited data on the pharmacokinetics of ...

journal_title：European journal of endocrinology

authors： Tong J,Dave N,Mugundu GM,Davis HW,Gaylinn BD,Thorner MO,Tschöp MH,D'Alessio D,Desai PB

更新日期：2013-05-02 00:00:00

abstract：OBJECTIVE:In the field of fine-needle aspiration cytology, the category of suspicious for malignancy (SM) thyroid lesions, that bears 55-85% risk of malignant histology, is a challenging topic in which morphology alone is not always able to make a correct diagnosis. Recently, immunocytochemistry (ICC) has been referred...

journal_title：European journal of endocrinology

authors： Rossi ED,Martini M,Capodimonti S,Straccia P,Cenci T,Lombardi CP,Pontecorvi A,Larocca LM,Fadda G

更新日期：2013-05-02 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients. DESIGN:Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment ...

journal_title：European journal of endocrinology

authors： Shao C,Huo N,Zhao L,Gao Y,Fan X,Zheng Y,Wang L,Lu H,Xu X,Guo X

更新日期：2013-04-15 00:00:00

abstract：OBJECTIVE:Klotho is a lifespan-influencing gene expressed mainly in the kidneys. Soluble α-Klotho (αKL) is released into the circulation. In this study, we present baseline αKL serum levels of patients with acromegaly compared with controls with other pituitary adenomas and assess changes following transsphenoidal surg...

journal_title：European journal of endocrinology

authors： Neidert MC,Sze L,Zwimpfer C,Sarnthein J,Seifert B,Frei K,Leske H,Rushing EJ,Schmid C,Bernays RL

更新日期：2013-03-15 00:00:00

abstract：:Klinefelter syndrome, 47,XXY (KS), is the most frequent sex chromosome aberration in males, affecting 1 in 660 newborn boys. The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoos...

journal_title：European journal of endocrinology

authors： Aksglaede L,Juul A

更新日期：2013-03-15 00:00:00

abstract：:Little is known about patients with malignant digestive neuroendocrine tumours (MD-NETs). Although their incidence is increasing, MD-NETs remain a rare cancer, representing 1% of digestive cancers. Most MD-NETs are well-differentiated. MD-NET poorly differentiated carcinomas account for 20% of cases on average. Anatom...

journal_title：European journal of endocrinology

authors： Lepage C,Bouvier AM,Faivre J

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:Previous studies have suggested that infections are an important cause of death in patients with Addison's disease, but epidemiological studies on the frequency of infections in this population are lacking. OBJECTIVE:To assess and compare the incidence risk of infections in patients with primary adrenal ins...

journal_title：European journal of endocrinology

authors： Smans LC,Souverein PC,Leufkens HG,Hoepelman AI,Zelissen PM

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:Survival rates among childhood cancer survivors (CCS) have enormously increased in the last 40 years. However, this improvement has been achieved at the expense of serious late effects that frequently involve the endocrine system. AIM:To evaluate the cumulative incidence of endocrine diseases in a cohort of...

journal_title：European journal of endocrinology

authors： Brignardello E,Felicetti F,Castiglione A,Chiabotto P,Corrias A,Fagioli F,Ciccone G,Boccuzzi G

更新日期：2013-02-20 00:00:00

abstract：:Recombinant human GH has been licensed for use in adult patients with GH deficiency (GHD) for over 15 years. Early weight- and surface area-based dosing regimens were effective but resulted in supraphysiological levels of IGF1 and increased incidence of side effects. Current practice has moved towards individualised r...

journal_title：European journal of endocrinology

authors： Gasco V,Prodam F,Grottoli S,Marzullo P,Longobardi S,Ghigo E,Aimaretti G

更新日期：2013-02-20 00:00:00

abstract：CONTEXT:Steroidogenic acute regulatory (STAR) gene mutations lead to adrenal and gonadal failure. Interesting, though as yet unexplained, features are the formation of ovarian cysts and the potential presence of CNS findings. OBJECTIVE:To report biochemical, genetic, and long-term clinical data in five Greek patients ...

journal_title：European journal of endocrinology

authors： Sertedaki A,Dracopoulou M,Voutetakis A,Stefanaki K,Rontogianni D,Magiakou AM,Kanaka-Gantenbein C,Chrousos G,Dacou-Voutetakis C

更新日期：2013-02-15 00:00:00